Since its discovery more than a hundred years ago, X-radiation has become an indispensable tool in diagnostics. Despite its huge success, for example in imaging bone structure, X-ray diagnostics ultimately reaches its limits in the examination of soft tissue such as tumours in healthy tissue.
Our long-term goal in MAP is the development of conceptually new approaches for biomedical X-ray imaging and therapy which explicitly makes use of the high brilliance of compact laser-driven X-ray sources. These efforts include new approaches for X-ray nanoscopy and nano-tomography, improved contrast modalities for pre-clinical X-ray imaging applications and image processing algorithms.
The proposed activities range from fundamental research using state-of-the-art, large-scale X-ray synchrotron sources (e.g. PETRA III & ESRF) over applications at laser-driven compact X-ray sources being developed in Research Area A.3 (Laser-based high-energy particle and x-ray sources) to applied research and technology transfer projects aiming at the creation of improved biomedical device technology for clinical use. From a medical perspective, our work currently targets early cancer and osteoporosis diagnostics.
Main objectives for 2012-2017:
a) Development of soft-X-ray high-resolution sub-cellular microscopy based on brilliant laser-driven higher harmonic sources
b) Development of hard-X-ray coherent nano-tomography for high-resolution visualisation of 3D tumour and pathologic bone morphology
c) Demonstration of earlier tumour detection in-vivo small-animal models by using phase-contrast computed tomography at compact X-ray sources
d) Exploration of dark-field radiography and computer vector tomography for improved osteoporosis diagnostics
e) Implementation of advanced image reconstruction and visualisation algorithms for brilliant X-ray diagnostics and therapy