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Coan, Paola, Prof. Dr.

Paola Coan

Ludwig Maximilians University

Faculty of Medicine
Marchioninistr. 15 D
81377 Großhadern - München, Germany

Department of Physics
Am Coulombwall 1
85748 Garching, Germany

At present: Visiting scientist at the European Synchrotron Radiation Facility

Grenoble, France

Phone: +49 (0)89 289-54022
Fax: +49 (0)89 289-14072

MAP research area:

C.2 Preclinical and clinical imaging

C.2.1 Cartilage

C.2.8 Multi-scale liver imaging


07/2006 PhD in Physics at the Biomedical Beamline (ID17) of the European Synchrotron Radiation Facility (ESRF) - with registration at the “J. Fourier” University of Grenoble. Thesis subject: Development and application of the analyzer-based technique (AI) with hard X-rays

2002 Degree in Physics at the “G. Galilei” Physics Department of the University of Padova. Vote 110/110; Thesis title: “Development and application of phase contrast techniques in digital mammography with synchrotron radiation” (in Italian)

1995 High school scientific degree (Maturità scientifica), Liceo Scientifico Statale “M. Flaminio”, Vittorio Veneto - (TV), Italy. Vote 56/60

Academic career:

Since 11/2009 Associate Professorship (W2; tenure track) on X-ray light sources for Medical diagnostics (Faculty of Medicine at the Ludwig Maximilians University, Munich – Germany)

07/2007 - 11/2009 Post-doc position in the frame of the German excellence cluster MAP (The Munich-Centre for Advanced Photonics) at the European Synchrotron Radiation Facility (ESRF)

10/2006 - 07/2007 Junior Scientist position at the beamline BM5 of the European Synchrotron Radiation Facility (ESRF)

Research expertise and fields:

“Phase contrast” Imaging

Biomedical application of “Phase contrast” imaging techniques

Articular cartilage and metal implant healing study

Improved breast cancer detection

K-edge imaging for elemental quantitative extraction

Evaluation of the performances of imaging detectors

Imaging analysis and 3D rendering

Development and implementation of a software for the simulation of the “Phase contrast” signal.


First prize of the Best Scientific Paper Awards 2006 within the topic “Physics in Radiology” at the 12th European Congress of Radiology (Vienna, Austria) (03/2006)

LMUexcellent: bonus for the appointment as “Professorin” (2010)

Sonderprogramm “Neuberufene Professorinnen” (2010)

Selected publications:

A. Horng, E. Brun, A. Mittone, S. Gasilov, L. Weber, T. Geith, S. Adam-Neumair, S. Auweter, A. Bravin, M. Reiser, P. Coan, Cartilage and soft tissue imaging using X-rays - Propagation-based phase-contrast CT of the human knee in comparison to clinical imaging techniques and histology, accepted for publication in Investigative Radiology

S. Gasilov, A. Mittone, E. Brun, A. Bravin, S. Grandl, A. Mirone, P. Coan, Tomographic reconstruction of the refractive index with hard X-rays: an efficient method based on the gradient vector-field approach, accepted for publication in Optics Express

A. Bravin, P. Coan and P. Suortti, X-ray phase-contrast imaging: from pre-clinical applications towards clinics, Physics in Medicine and Biology 58, R1-35 (2013)

Y. Zhao and E. Brun (shared-first authorship), P. Coan, Z. Huang, A. Sztrókay, P. C. Diemoz, S. Liebhardt, A. Mittone, S. Gasilov, J. Miao and A. Bravin, High resolution, low dose phase contrast x-ray tomography for 3D diagnosis of human breast cancers, Proceedings of the National Academy of Sciences of the United States of America, 109(45), 18290-18294, ISSN: 1091-6490 (2012)

P. C. Diemoz, A. Bravin, M. Langer, P. Coan, Analytical and experimental determination of signal-to-noise ratio and figure of merit in three phase-contrast imaging techniques, Optics Express, 20(25) 27670-27690 (2012)

P.C. Diemoz, A. Bravin and P. Coan, Theoretical comparison of three X-ray phase-contrast imaging techniques: propagation-based imaging, analyzer-based imaging and grating interferometry, Optics Express, 20(3), 2789-2805 (2012)

P. Coan, A. Wagner, A. Bravin, P.C. Diemoz, J. Keyriläinen and J. Mollenhauer, In vivo X-ray phase contrast analyzer-based imaging for longitudinal osteoarthritis studies in guinea pigs, Physics in Medicine and Biology, 55(24), 7649-7662 (2010)

P. Coan, F. Bamberg, P.C. Diemoz, A. Bravin, K. Timpert, E. Mützel, J. Raya, M. Reiser and C. Glaser, Characterization of Osteoarthritic and Normal Human Patella Cartilage by Computed Tomography X-Ray Phase-Contrast Imaging:A feasibility Study, Investigative Radiology, 45(7) (2010)

P. Coan and A. Bravin, Analysis of the X-ray refraction using an array-structured detector, Applied Physics Letters, 90(18) (2007)

P. Coan, J. Mollenhauer, A. Wagner, C. Muehleman and A. Bravin, Analyzer-based imaging technique in tomography of cartilage and metal implants: A study at the ESRF, European Journal of Radiology, 68, S41-S48 (2008)