The aim of this project is to evaluate and establish grating-based phase contrast imaging (PCI) for visualization and characterization of renal parenchymal diseases and renal masses. We will employ the following steps:
(1) use and optimize the technical grating-based PCI at the TUM Garching to acquire 3D tomographies of phase contrast, absorption contrast and dark-field signals of kidney parenchyma ex vivo;
(2) compare PCI, dark-field and absorption image characteristics for visualizing and differentiation of parenchymal renal disease ex vivo using animal models;
(3) investigate PCI characteristics of explanted renal transplants in correlation to CT or MRI images and histopathology;
(4) compare PCI image characteristics of normal human kidney tissue and renal masses ex vivo with unenhanced CT, MRI (see also Fig. C.2.7) and histopathology;
Various animal models for parenchymal (e.g. acute renal transplant rejection) or glomerular diseases (e.g. glomerulonephritis, diabetes mellitus) will be employed.