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Wilkens, Jan, Prof. Dr.

Jan Wilkens

Technische Universität München (TUM)

Klinikum rechts der Isar
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
Ismaninger Str. 22

81675 Munich, Germany

Phone: +49 (0)89 4140-4504
Fax: +49 (0)89 4140-4881

MAP research areas:


C.1 Biomedical physics and technology

C.3 Radiotherapy and radiation biology

C.3.2 Radiation therapy with laser-driven ion beams

C.3.5 Radiation therapy with brilliant X-ray beams


2004 DSc (Dr. rer. nat.) in Physics, University of Heidelberg
2002 Certificate in Medical Physics and Engineering, University of Kaiserslautern
2001 Degree in Physics (Dipl.-Phys.), Ludwig-Maximilians-Universität Munich

Academic Career:

Since 2008 Professor (W2) for “Advanced Technologies in Radiation Therapy”, Faculty of Medicine, Technische Universität München
2006 Post Doctoral Research Associate at Washington University in St. Louis, MO (USA), School of Medicine
2004 - 2008 Research Associate at German Cancer Research Center (DKFZ) in Heidelberg, Department of Medical Physics in Radiation Oncology
2003 Research Fellow at Massachusetts General Hospital, North-East Proton Therapy Center, Boston, MA, USA

Research expertise and fields:

Medical physics in radiation therapy

Radiotherapy with proton and ion beams

Optimisation techniques for treatment planning

Analytical and Monte Carlo dose calculation

Radiobiological modeling

Image-guided radiation therapy

Functional and biological imaging techniques

Laser-accelerated particle beams for radiotherapy


Scholarships awarded by Evangelisches Studienwerk e.V. Villigst, ERASMUS • and German Cancer Research Center

Postgraduate fellowship by German Academic Exchange Service (DAAD)

Selected publications:

Girst S., C. Greubel, J. Reindl, C. Siebenwirth, O. Zlobinskaya, D.W.M. Walsh, K. Ilicic, M. Aichler, A. Walch, J.J. Wilkens, G. Multhoff, G. Dollinger, T.E. Schmid: “Proton minibeam radiotherapy reduces side effects in an in-vivo mouse ear model” International Journal of Radiation Oncology, Biology, Physics 95(1), 234-41, 2016.

Kamp F., G. Cabal, A. Mairani, K. Parodi, J.J. Wilkens, D.J. Carlson: “Fast biological modeling for voxel-based heavy ion therapy treatment planning using the mechanistic repair-misrepair-fixation (RMF) model and nuclear fragment spectra” International Journal of Radiation Oncology, Biology, Physics 93(3), 557-568, 2015.

Hofmann K.M., U. Masood, J. Pawelke, J.J. Wilkens: “A treatment planning study to assess the feasibility of laser-driven proton therapy using a compact gantry design” Medical Physics 42(9), 5120-5129, 2015.

Girst S., C. Marx, E. Bräuer-Krisch, A. Bravin, S. Bartzsch, U. Oelfke, C. Greubel, J. Reindl, C. Siebenwirth, O. Zlobinskaya, G. Multhoff, G. Dollinger, T.E. Schmid, J.J. Wilkens: “Improved normal tissue protection by proton and x-ray microchannels compared to homogeneous field irradiation” Physica Medica 31(6) 615-620, 2015.

Faby S., J.J. Wilkens: “Assessment of Secondary Radiation and Radiation Protection in Laser-Driven Proton Therapy” Zeitschrift für Medizinische Physik 25(2), 112-122, 2015.

Müller B.S., M.N. Duma, S. Kampfer, S. Nill, U. Oelfke, H. Geinitz, J.J. Wilkens: “Impact of interfractional changes in head and neck cancer patients on the delivered dose in intensity modulated radiotherapy with protons and photons” Physica Medica 31(3), 266-272, 2015.

Kamp F., S. Brüningk, G. Cabal, A. Mairani, K. Parodi, J.J. Wilkens: “Variance-based sensitivity analysis of biological uncertainties in carbon ion therapy” Physica Medica 30(5), 583-587, 2014. 

Bin J., K. Allinger, W. Assmann, G. Dollinger, G.A. Drexler, A.A. Friedl, D. Habs, P. Hilz, R. Hoerlein, N. Humble, S. Karsch, K. Khrennikov, D. Kiefer, F. Krausz, W. Ma, D. Michalski, M. Molls, S. Raith, S. Reinhardt, B. Röper, T.E. Schmid, T. Tajima, J. Wenz, O. Zlobinskaya, J. Schreiber and J.J. Wilkens: “A laser-driven nanosecond proton source for radiobiological studies” Applied Physics Letters 101, 243701, 2012.

Hofmann K.M., S. Schell and J.J. Wilkens: “Laser-driven beam lines for delivering intensity modulated radiation therapy with particle beams” J. Biophotonics 5(11-12), 903-911, 2012.