Munich-Centre for Advanced Photonics

Biomedical physics and technology

Coherent nano-CTuses multiple coherent X-ray diffraction images (indicated on the left) to compute a high-resolution three-dimensional digital image of the sample. Applied in osteology, the process helps to visualise the fine network of channels about 100 nanometers in size, through which bone cells connect with each other

Since its discovery more than a hundred years ago, X-radiation has become an indispensable tool in medical diagnostics. Despite its huge success, for example in imaging bone structure, X-ray diagnostics ultimately reaches its limits in the examination of soft tissue such as tumours in healthy tissue. 
Our long-term goal in MAP is the development of conceptually new approaches for biomedical X-ray imaging and therapy which explicitly make use of the high brilliance of compact laser-driven X-ray sources. These efforts include new approaches for X-ray nanoscopy and nano-tomography, improved contrast modalities for pre-clinical X-ray imaging applications and image processing algorithms. The proposed activities range from fundamental research using state-of-the-art, large-scale X-ray synchrotron sources (e.g. PETRA III & ESRF) over applications at laser-driven compact X-ray sources being developed in Research Area A.3 to applied research and technology transfer projects aiming at the creation of improved biomedical device technology for clinical use. From a medical perspective, our work currently targets early cancer and osteoporosis diagnostics.

Our long-term goals and visions
Our long-term goal within MAP is the development of conceptually new approaches for biomedical X-ray imaging and therapy which explicitly make use of the high brilliance of compact laser-driven X-ray sources. These efforts include new approaches for X-ray nanoscopy improved contrast modalities for pre-clinical X-ray imaging applications and advanced image processing algorithms. The proposed activities range from fundamental research and benchmarking experiments using state-of-the-art, large-scale X-ray synchrotron sources (PETRA III & ESRF) over applications at laser-driven compact X-ray sources that are being developed in Research Area A.3 to applied research and technology transfer projects aiming at the creation of improved biomedical device technology for clinical use. From a medical perspective, our work will primarily target early cancer and osteoporosis diagnostics.

Projects

C.1.1 | Soft-X-ray high-resolution sub-cellular microscopy based on brilliant laser-driven higher harmonic sources (Ulf Kleineberg, Anna Friedl and Janos Hajdu)

C.1.2 | Hard-X-ray coherent nano-tomography for high-resolution visualisation of 3D tumour and pathologic bone morphology (Irene Zanette and Pierre Thibault)

C.1.3 | Earlier tumour detection in in-vivo small-animal models by phase-contrast CT at compact X-ray sources (Martin Bech and Gabriele Multhoff)

C.1.4 | Dark-field radiography and computer vector tomography for improved osteoporosis diagnostics (Michael Chabior and Annie Horng)

C.1.5 | Advanced image reconstruction and visualisation algorithms for brilliant X-ray diagnostics and therapy (Tobias Lasser)

SCIENTISTS

Coordinator:
Franz Pfeiffer

Deputy Coordinators:
Fridtjof Nüsslin, Gabriele Multhoff

Principal Investigators:
U. Kleineberg, G. Multhoff, F. Pfeiffer, M. Reiser, J. Wilkens

Other Project Leaders:
M. Bech, A. Friedl, J. Hajdu, A. Horng, T. Lasser, N. Navab, P. Thibault

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